Health Impacts of Air Pollution

Posted by Stop Ajax Mine on April 11th, 2013 8:44am

The following list of citations were provided by Dr. Moench regarding air pollution and it's impact on our health. This is nothing to say we are going to turn into Salt Lake City or have as much air pollution as Salt Lake City, but it shows how significant an impact air pollution has on our health. With the Ajax mine proposing to burn 91,000 litres of diesel fuel EVERY DAY, it will of course create more air pollution that is blown over the rest of our town.     


Here's the list for your reference, notice how most ofthese are published in the last 5-10 years? Perhaps government has some catching up to do regarding our air pollution and air quality guidelines...

1. Calderon-Garciduenas L, Mora-Tiscareno A, Ontiveros E, et al.  Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs.  Brain Cogn. 2008 Nov;68(2):117-27. Epub 2008 Jun 11..


2. Calderon-Garciduenas L, Solt AC, et al.  Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. Toxicol Pathol. 2008;36(2):289-310. Epub 2008 Mar 18


3.  Calderon-Garciduenas L, Franco-Lira M, Torres-Jardon R.  Pediatric Respiratory and Systemic Effects of Chronic Air Pollution Exposure:  Nose, Lung, Heart, and Brain Pathology.  Toxicol Pathol, Vol. 35, No1, 154-162 (2007)


4.  Hartz A, Bauer B, Block M, Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein, up-regulation at the blood-brain barrier.  The FASEB Journal 2008;22:2723-2733.


5.  Cruts B, van Etten L, Tornquvist H, et al.  Exposure to diesel exhaust induces changes in EEG in human volunteers.  Part Fibre Toxicol. 2008;5:4. March11. dol:1186/1743-8977-5-4.


6.  Suglia SF, et al.  Association of Black Carbon with Cognition among Children in a Prospective Birth Cohort Study Am J Epidemiology 2008 167:280-286.


7.  Wang, Z., Zeng, X, Zeng, Y, Wang, S. Chen, S.  Association of traffic-related air pollution with children’s neurobehavioral functions in Quanzhou, China.  Environ Health Perspect. 2009 Oct; 117 (10):1612-8 Epub. 2009 May 11.


8.  Volk H, Hertz-Picciotto I,  Delwiche L ,  Lurmann F,  McConnell R.  Residential Proximity to Freeways and Autism in the CHARGE study.  Environ Health Perspect. 2010 Dec 13. [Epub ahead of print] PMID: 21156395.


9.  Morales, E.,  Julvez, J.,  Torrent, M., et al.   Association of Early-life Exposure to Household Gas Appliances and Indoor Nitrogen Dioxide With Cognition and Attention Behavior in Preschoolers.  American Journal of Epidemiology 2009 169(11):1327-1336; 


10.  Suzuki, T.,  Oshio, S.,  Iwata, M.,  et al.  In utero exposure to a low concentration of diesel exhaust affects spontaneous locomotor activity and monoaminergic system in male mice.  Particle and Fibre Toxicology 2010, 7:7doi:10.1186/1743-8977-7-7


11.  Freire, C.,  Ramos, R.,  Puertas,  R., et al.   Association of traffic-related air pollution with cognitive development in children.  J Epidemiol Community Health  2010;64:223-228


12.  Edwards SC, Jedrychowski W, Butscher M, Camann D, Kieltyka A, Mroz E, et al. 2010. Prenatal Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Children’s Intelligence at Age 5 in a Prospective Cohort Study in Poland. Environ Health Perspect :-. doi:10.1289/ehp.0901070  


13.  Calderón-Garcidueñas L, Reed W, Maronpot RR, Henríquez-Roldán C, Delgado-Chavez R, Calderón-Garcidueñas A, Dragustinovis I, Franco-Lira M, Aragón-Flores M, Solt AC, Altenburg M, Torres-Jardón R, Swenberg JA.  Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution. Toxicol Pathol. 2004 Nov-Dec;32(6):650-8.


14.  Power MC, Weisskopf MG, Alexeeff SE, Coull BA, Spiro Iii A, Schwartz J.  Traffic-Related Air Pollution and Cognitive Function in a Cohort of Older Men.  Harvard School of Public Health.  Environ Health Perspect. 2010 Dec 20. [Epub ahead of print]


15.  G. Oberdörster‌, Z. Sharp‌, V. Atudorei‌, A. Elder‌, R. Gelein‌, W. Kreyling‌ and C. Cox‌. Translocation of Inhaled Ultrafine Particles to the Brain.  Inhalation Toxicology 2004, Vol. 16, No. 6-7, Pages 437-445


16.  Perera, FP, L Zhigang, R Whyatt, L Hoepner, S Wang, D Camann and V Rauh. 2009. 2009. Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years. Pediatrics doi: 10.1542/peds.2008-3506.


17.   Lopez I,  Beltran-Parrazal1 L,  Abhimanyu Amarnani A.  Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air) BMC Neuroscience 2009, 10:53doi:10.1186/1471-2202-10-53


18.  Zhou Z, Yuan T,  Chen Y, Qu L, Rauh V,  Zhang Y,  Tang D, Perera F, Li T.  Benefits of Reducing Prenatal Exposure to Coal-Burning Pollutants to Children’s Neurodevelopment in China   Research Article, published 14 Jul 2008 | doi:10.1289/ehp.11480


19.  Thomson, E.M. et al. (2007) Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression. Environ. Res. 105, 224233


20.  Peters, A. et al. (2006) Translocation and potential neurological effects of fine and ultrafine particles a critical update. Part. Fibre Toxicol. 3, 13 



23.  Calderon-Garciduenas, L. et al. (2002) Air pollution and brain damage. Toxicol. Pathol. 30, 373–389 


24.  Calderon-Garciduenas, L. et al. (2003) DNA damage in nasal and brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and neurodegeneration. Toxicol. Pathol. 31, 524–538 




26.  Lopez IA, Acuna D, Beltran-Parrazal L, Lopez IE, Amarnani A, Cortes M, Edmond J.  Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air)  BMC Neuroscience 2009, 10:53 (27 May 2009)


27. Morgan TE, Davis DA, Iwata N, Tanner JA, Snyder D, Ning Z, et al. 2011. Glutamatergic Neurons in Rodent Models Respond to Nanoscale Particulate Urban Air Pollutants In Vivo and In Vitro. Environ Health Perspect :-. doi:10.1289/ehp.1002973


28.  Gackière F, Saliba L, Baude A, Bosler O, Strube C.  Ozone inhalation activates stress-responsive regions of the central nervous system.  J Neurochem. 2011 Apr 6. doi: 10.1111/j.1471-4159.2011.07267.x. [Epub ahead of print]


29.  Calderón-Garcidueñas L, D'Angiulli A, Kulesza RJ, Torres-Jardón R, Osnaya N, Romero L, Keefe S, Herritt L, Brooks DM, Avila-Ramirez J, Delgado-Chávez R, Medina-Cortina H, González-González LO.  Air pollution is associated with brainstem auditory nuclei pathology and delayed brainstem auditory evoked potentials.  Int J Dev Neurosci. 2011 Mar 31. [Epub ahead of print]


30.  Power MC, Weisskopf MG, Alexeeff SE, Coull BA, Spiro A III, Schwartz J 2011. Traffic-Related Air Pollution and Cognitive Function in a Cohort of Older Men. Environ Health Perspect 119:682-687. doi:10.1289/ehp.1002767


31.  Fonken LK,  Xu X,  Weil ZM,  Chen G,  Sun Q,  Rajagopalan S,  Nelson RJ. Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology. Molecular Psychiatry, 2011; DOI: 10.1038/mp.2011.76


32.  Levesque S, Surace MJ, McDonald J, Block ML.  Air pollution and the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease.  J Neuroinflammation. 2011 Aug 24;8(1):105. [Epub ahead of print]


33.  Guxens M, Aguilera I, Ballester F, Estarlich M, Fernández-Somoano A, Lertxundi A, Lertxundi N, Mendez MA, Tardón A, Vrijheid M, Sunyer J.  Prenatal Exposure to Residential Air Pollution and Infant Mental Development: Modulation by Antioxidants and Detoxification Factors.  Environ Health Perspect. 2011 Aug 25. [Epub ahead of print]


34.   Calderón-Garcidueñas L, Kavanaugh M, Block M, D'Angiulli A, Delgado-Chávez R, Torres-Jardón R, González-Maciel A, Reynoso-Robles R, Osnaya N, Villarreal-Calderon R, Guo R, Hua Z, Zhu H, Perry G, Diaz P.  Neuroinflammation, Alzheimer's Disease-Associated Pathology, and Down-Regulation of the Prion-Related Protein in Air Pollution Exposed Children and Young Adults.

J Alzheimers Dis. 2011 Sep 28. [Epub ahead of print]


35.   Calderón-Garcidueñas L, Engle R, Mora-Tiscareño A, Styner M, Gómez-Garza G, Zhu H, Jewells V, Torres-Jardón R, Romero L, Monroy-Acosta ME, Bryant C, González-González LO, Medina-Cortina H, D'Angiulli A.   Exposure to severe urban air pollution influences cognitive outcomes, brain volume and systemic inflammation in clinically healthy children.  Brain Cogn. 2011 Oct 25. [Epub ahead of print]


36.  Ranft U, Schikowski T, Sugiri D, Krutmann J, Krämer U.  Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly.  Environ Res. 2009 Nov;109(8):1004-11. Epub 2009 Sep 4.


37.  Henn BC, Schnaas L, Ettinger AS, Schwartz J, Lamadrid-Figueroa H, Hernández-Avila M, et al. 2011. Associations of Early Childhood Manganese and Lead Coexposure with Neurodevelopment. Environ Health Perspect 120:126-131.


38.  Ciesielski T, Weuve J, Bellinger DC, Schwartz J, Lanphear B, Wright RO 2012. Cadmium Exposure and Neurodevelopmental Outcomes in U.S. Children. Environ Health Perspect :-.


39.   Weuve J,  Puett R,  Schwartz  J,  Yanosky J,  Laden F,  Grodstein F.   Exposure to Particulate Air Pollution and Cognitive Decline in Older Women Arch Intern Med. 2012;172(3):219-227. doi:10.1001/archinternmed.2011.683


40.  Perera FP, Tang D, Wang S, Vishnevetsky J, Zhang B, Diaz D, Camann D, Rauh V.  Prenatal Polycyclic Aromatic Hydrocarbon (PAH) Exposure and Child Behavior at age 6-7.  Environ Health Perspect. 2012 Mar 22. [Epub ahead of print]


41.  Calderón-Garcidueñas L, Serrano-Sierra A, Torres-Jardón R, Zhu H, Yuan Y, Smith D, Delgado-Chávez R, Cross JV, Medina-Cortina H, Kavanaugh M, Guilarte TR.  The impact of environmental metals in young urbanites' brains.  Exp Toxicol Pathol. 2012 Mar 19. [Epub ahead of print]


42.  Lewis J, Bench G, Myers O, Tinner B, Staines W, Barr E, Divine KK, Barrington W, Karlsson J (2005) Trigeminal uptake and clearance of inhaled manganese chloride in rats and mice. Neurotoxicology 26:113–23.


43.   Calderón-Garcidueñas L, Mora-Tiscareño A, Styner M, Zhu H, Torres-Jardón R, Carlos E, Solorio-López E, Medina-Cortina H, Kavanaugh M, D'Angiulli A.  White Matter Hyperintensities, Systemic Inflammation, Brain Growth, and Cognitive Functions in Children Exposed to Air Pollution.

J Alzheimers Dis. 2012 Apr 18. [Epub ahead of print]


44.  Moulton PV, Yang W.  Air pollution, oxidative stress, and Alzheimer's disease.  J Environ Public Health. 2012;2012:472751. Epub 2012 Mar 15.


45.  Bos I, De Boever P, Emmerechts J, Buekers J, Vanoirbeek J, Meeusen R, Van Poppel M, Nemery B, Nawrot T, Panis LI.  Changed gene expression in brains of mice exposed to traffic in a highway tunnel.  Inhal Toxicol. 2012 Aug;24(10):676-86.


46.  Boucher O, et al.   Prenatal Methylmercury, Postnatal Lead Exposure, and Evidence of Attention Deficit/Hyperactivity Disorder among Inuit Children in Arctic Québec.  Environ Health Perspect 120:0000–0000 (2012). [Online 21 September 2012]


47.  Volk H, Lurmann F, Penfold B, Hertz-Picciotto I, McConnell R.  Traffic-Related Air Pollution, Particulate Matter, and Autism.  Arch Gen Psychiatry. 2012;():1-7. doi:10.1001/jamapsychiatry.2013.266.


48.  Chen R, Zhang Y, Yang C, Zhao Z, Xu X, Kan H.  Acute Effect of Ambient Air Pollution on Stroke Mortality in the China Air Pollution and Health Effects Study.

Stroke. 2013 Feb 7. [Epub ahead of print]


49.  Allen, JL, K Conrad, G Oberdörster, CJ Johnston, B Sleezer and BA Cory-Slechta. 2013. Developmental exposure to concentration ambient particles and preferences for immediate reward in mice. Environmental Health Perspectives 121(1): 32-38


50.  Becerra T,   Wilhelm M, Olsen J, Cockburn M, Ritz B.   Ambient Air Pollution and Autism in Los Angeles County, California.  Environ Health Perspect 121:380–386 (2013). [Online 18 December 2012]


51.  Lucchini, RG, S Zoni, S Guazzetti, E Bontempi, S Micheletti, K Broberg, G Parrinello and DR Smith. 2012. Inverse association of intellectual function with very low blood lead but not with manganese exposure in Italian adolescents. Environmental Research


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